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p-Dioxane or 1,4-Dioxane or para-Dioxane Chemically SDS Safety Data Sheet of Supplier Exporter Manufacturers' Representative |
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p-Dioxane or 1,4-Dioxane or para-Dioxane
CAS Number: 123-91-1
Molecular Formula: C4H8O2
Molecular Weight: 88.11
p-Dioxane or 1,4-Dioxane or para-Dioxane
1,4-Dioxane or p-Dioxane SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 01-Feb-26
1. Product Identification
Product Name & Other Names: 1,4-Dioxane or p-Dioxane.
CAS No.: 123-91-1
EINECS EC Number: 204-661-8
Molecular Formula: C4H8O2
Molecular Weight: 88.11
Recommended use: Industrial Manufacturing.
Supplier: American Molecules, 9910 Bent Oak Dr, Houston, TX 77040, USA.
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665.
In case of emergency contact: Will be given with the supply.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Flammable liquids Category 2, H225
Serious eye damage/eye irritation Category 1, H319
Specific target organ toxicity - single exposure Category 3, Respiratory system, H335
Carcinogenicity Category 2, H351
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements  Irritant | GHS Label Elements  Flammable | GHS Label Elements  Health Hazard |
Signal Words: Danger
Hazard statements:
H225 Highly flammable liquid and vapour.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H351 Suspected of causing cancer.
Precautionary statements:
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P210: Keep away from heat/sparks/open flames/hot surfaces – No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/light/…/equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P314: Get Medical advice/attention if you feel unwell.
P330: Rinse mouth.
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P303+361+353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P302+P352: IF ON SKIN: Wash with soap and water.
P305+P351+ 338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308+313: IF exposed or concerned: Get medical advice/attention.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P370+378: In case of fire: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide for extinction.
P403+235: Store in a well ventilated place. Keep cool.
P404: Store in a closed container.
P405: Store locked up.
P501: Dispose of contents/ container to an approved waste disposal plant.
3. Composition/Information on Ingredients
Product Name & Other Names: 1,4-Dioxane or p-Dioxane.
CAS No.: 123-91-1
EINECS EC Number: 204-661-8
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately.
Ingestion: If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. Get medical attention immediately.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention immediately. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Fire: Flammable.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Further information: Use water spray to cool unopened containers.
Special hazards arising from the substance or mixture: Carbon oxides and Toxic fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.
7. Handling and Storage
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Use only outdoors or in a well-ventilated area. Wear suitable protective equipment during handling. Keep away from sources of ignition - No smoking. Take measures to prevent the buildup of electrostatic charge.
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials like Oxidizing agents, Oxygen, Halogens, Reducing agents, Perchlorates., etc. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, strong bases, and metals.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: USA ACGIH TLV TWA 20 ppm skin.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): If the exposure limit is exceeded, a full face piece respirator with dust/mist filter may be worn up to 50 times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: Colorless Liquid.
Odor: Faint sweet ether-like odor.
Odor threshold: Not available.
pH: 6 to 8
Relative density: about 1.03
Boiling Point: 111.1C literature.
Melting Point: 11.8C literature.
Flash Point: 12C literature.
Auto-ignition temperature: 180C.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Miscible with water.
Viscosity: Not available.
Molecular Formula: C4H8O2
Molecular Weight: 88.11
10. Stability and Reactivity
Stability: It is stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: When heated to decomposition it emits Carbon oxides and toxic fumes.
Hazardous Polymerization: Will not occur.
Incompatibilities: Oxidizing agents, Oxygen, Halogens, Reducing agents, Perchlorates., Trimethylaluminum.
Conditions to Avoid: Incompatibles, open flames, hot surfaces, and sources of ignition.
11. Toxicological Information
LD50 Oral - Rat - male: 4.200 mg/kg.
LC50 Inhalation - Rat - 2 h: 46000 ppm.
LD50 Dermal - Rabbit - 7858 mg/kg.
Carcinogenic Effects: This product contains one or more substances which are classified by IARC as carcinogenic to humans, possibly carcinogenic to humans (Group 2B).
Mutagenic Effects: Not available.
12. Ecological Information
Toxicity to fish: LC50 - Pimephales promelas (fathead minnow) - 985 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna (Water flea) - 8.450 mg/l - 24 h.
Persistence and degradability: Persistence is unlikely due to water solubility.
Bioaccumulative potential: Not available.
Mobility: Will likely be mobile in the environment due to its volatility and water solubility.
Results of PBT and vPvB assessment: Not available.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state, and local requirements.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe
Proper Shipping Name: DIOXANE
Hazard Class: 3; Packing Group: II
UN/NA: 1165
IMDG/IMO & IATA/ICAO
Proper Shipping Name: DIOXANE
Hazard Class: 3; Packing Group: II
UN/NA: 1165
15. Regulatory Information
SARA 311/312: Acute Health Hazard, Chronic Health Hazard. See section 2.
SARA 313: Listed.
California Proposition 65: This product does not contain any Proposition 65 chemicals.
Section 16 - Additional Information
European Labeling in Accordance with EC Directives:
H225 Highly flammable liquid and vapor.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H351 Suspected of causing cancer.
EUH019 May form explosive peroxides.
EUH066 Repeated exposure may cause skin dryness or cracking.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Please visit Main Page of p-Dioxane or 1,4-Dioxane or para-Dioxane Suppliers.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
Suppliers and Manufacturers' Representative:
9910 Bent Oak Dr
Houston, TX 77040, USA
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665
Email: info@ammol.org