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Tolperisone HCl or Tolperisone Hydrochloride
CAS Number: 3644-61-9
Molecular Formula: C16H24ClNO
Molecular Weight: 281.82
Tolperisone HCl or Tolperisone Hydrochloride
Tolperisone SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 25-August-2026
1. Product Identification
Product Name & Other Names: Tolperisone.
CAS No.: 728-88-1
EINECS EC Number: 211-976-4
Molecular Formula: C16H23NO
Molecular Weight: 245.37
Relevant uses and uses advised against (if any): Laboratory and Industrial Use.
Supplier: American Molecules, 9910 Bent Oak Dr, Houston, TX 77040, USA.
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665.
In case of emergency contact: Will be given with the supply.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral (Category 4) H302
Acute toxicity, dermal (Category 4) H312
Acute toxicity, Inhalation (Category 4) H332
Labeling according to GHS USA & Regulation (EC) No 1272/2008
GHS Label Elements Harmful |
Signal Words: Warning
Hazard Statements:
H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled.
Precautionary Statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash contaminated parts thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P303+361+353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340+P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/national regulation.
3. Composition/Information on Ingredients
Product Name & Other Names: Tolperisone.
CAS No.: 728-88-1
EINECS EC Number: 211-976-4
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do not use mouth-to-mouth method if victim inhaled the substance. Induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Get medical attention.
Ingestion: Rinse mouth. Do not induce vomiting without medical advice. If vomiting occurs naturally, have victim lean forward to reduce the risk of aspiration. Never give anything by mouth to a victim who is unconscious or is having convulsions. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Use a mild soap if available. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse. For minor skin contact, avoid spreading material on unaffected skin.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Products of Combustion: Carbon oxides, Nitrogen oxides and fumes.
Fire Extinguishing Media: Water spray. Alcohol foam. Polymer foam. Dry chemical powder. Carbon dioxide (CO2). Avoid a solid water stream as it may scatter and spread fire. Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations. In the event of fire and/or explosion do not breathe fumes.
Special Information: Fire may produce irritating, corrosive and/or toxic gases. In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Personal precautions: Ensure adequate ventilation. Keep people away from upwind of spill/leak. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Ventilate closed spaces before entering. Keep out of low areas.
Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not contaminate water.
Methods for cleaning up: Clean up in accordance with all applicable regulations. Should not be released into the environment. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep up and remove to an approved disposal container.
7. Handling and Storage
Precautions for safe handling: Keep away from sources of ignition - No smoking. Do not handle or store near an open flame, heat, or other sources of ignition. Use only under a chemical fume hood. Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Avoid prolonged exposure. Do not empty into drains.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong acids, strong bases, strong oxidizing agents, strong reducing agents. Storage: Store the container tightly closed in a dry, cool and well-ventilated place. Store below 25C. Do not freeze or leave the medication in hot environments. Exposure to direct light and moisture can degrade the active ingredients. Store at refrigerator (2C to 8C) for long term storage.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties
Appearance: White to off-white crystalline powder.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Boiling point: No data found.
Melting point/Freezing point: 176C to 177C literature. Official pharmacological data, Japanese Pharmacopeia, cite a melting range of 167C to 174C, while bulk chemical distributors list it between 168C and 183C.
Flash Point: 180C.
Auto-ignition Temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility (water): Freely soluble in water and ethanol.
Viscosity: No data found.
10. Stability and Reactivity
Stability: It is stable under recommended conditions of use and storage.
Hazardous Decomposition Products: It emits carbon oxides, nitrogen oxides and fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, strong reducing agents.
Conditions to Avoid: Avoid light, heat, sparks, open flames and other ignition sources. Contact with incompatible materials.
11. Toxicological Information
Toxicity data: No data found.
Carcinogenicity: Not expected to be hazardous by IARC, NTP, ACGIH and OSHA criteria.
Mutagenic Effects: No data found.
Reproductive Effects: No data found.
Developmental Effects: No data found.
Teratogenicity: No data found.
12. Ecological Information
Toxicity to fish: No data found.
Persistence and degradability: Persistent is unlikely.
Mobility in soil: Likely to be mobile.
Results of PBT and vPvB assessment: Not PBT and vPvB.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate nd approved waste disposal facility.
14. Transport Information
Department of Transportation DOT USA & ADR/RID Europe: Not controlled.
TDG & IMDG/IMO: Not controlled.
IATA: Not controlled.
15. Regulatory Information
USA:
SARA 311/312 Hazards: See section 2.
California Prop. 65 Components: Not listed.
Section 16 - Additional Information
European Labeling in Accordance with EC Directives:
H302+H312+H332: Harmful if swallowed, in contact with skin or if inhaled.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Please visit Main Page of Tolperisone HCl or Tolperisone Hydrochloride Suppliers.
American Molecules, also known as ammol.org is a distributor, supplier and manufacturers' representative of all types of Pharmaceuticals, Functional Ingredients, Excipients and Specialty Chemicals in Texas USA. Our principals manufacture supply and export USP NF BP, Ph Eur, etc grades of chemicals pure and reagent grade, mineral fortifiers, FCC food grade. Tailor made particle size and customized specifications are offered. The principal's facility is having one or more of the certifications like FDA approval and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) for export to Europe is available. The manufacturers suppliers and exporters observe WHO Good Manufacturing Practices and Good Laboratory Practices.
Suppliers and Manufacturers' Representative:
9910 Bent Oak Dr
Houston, TX 77040, USA
Call Toll Free: 1-855-55-AMMOL 1-855-552-6665
Email: info@ammol.org